Abstract
Owing to our current interest in synthesizing and evaluating the antiulcer and antisecretory activity of bicyclic compounds, a series of 1(or 3),4,6,7-tetrahydropyrano- and 1(or 3),4,6,7-tetrahydrothiopyrano-[3,4-d]imidazoles was synthesized and tested. The biological results were compared with those of some previously described 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine and 4,5,6,7-tetrahydrobenzimidazole derivatives.
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Chemistry, Physical
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Gastric Juice / metabolism
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Guinea Pigs
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Mice
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Pyrans / chemical synthesis*
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Pyrans / pharmacology
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Rats
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Stomach Ulcer / etiology
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Stomach Ulcer / physiopathology
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Stomach Ulcer / prevention & control*
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Stress, Psychological / complications
Substances
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Anti-Ulcer Agents
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Imidazoles
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Pyrans