Breathing new insights into the role of mutant p53 in lung cancer

Tianwei Chen; Lauren M Ashwood; Olga Kondrashova; Andreas Strasser; Gemma Kelly; Kate D Sutherland

doi:10.1038/s41388-024-03219-6

Breathing new insights into the role of mutant p53 in lung cancer

Oncogene. 2025 Feb;44(3):115-129. doi: 10.1038/s41388-024-03219-6. Epub 2024 Nov 20.

Authors

Tianwei Chen^{1

2}, Lauren M Ashwood^{3

4}, Olga Kondrashova^{3

4}, Andreas Strasser^{5

6}, Gemma Kelly^{7

8}, Kate D Sutherland^{9

10}

Affiliations

¹ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
² Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
³ QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
⁴ The University of Queensland, Brisbane, QLD, Australia.
⁵ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. [email protected].
⁶ Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. [email protected].
⁷ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. [email protected].
⁸ Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. [email protected].
⁹ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. [email protected].
¹⁰ Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. [email protected].

Abstract

The tumour suppressor gene p53 is one of the most frequently mutated genes in lung cancer and these defects are associated with poor prognosis, albeit some debate exists in the lung cancer field. Despite extensive research, the exact mechanisms by which mutant p53 proteins promote the development and sustained expansion of cancer remain unclear. This review will discuss the cellular responses controlled by p53 that contribute to tumour suppression, p53 mutant lung cancer mouse models and characterisation of p53 mutant lung cancer. Furthermore, we discuss potential approaches of targeting mutant p53 for the treatment of lung cancer.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology
Mice
Mutation*
Tumor Suppressor Protein p53* / genetics
Tumor Suppressor Protein p53* / metabolism

Substances

Tumor Suppressor Protein p53

Abstract

Publication types

MeSH terms

Substances

Grants and funding