The potential role of CGRP in synuclein-associated neurodegenerative disorders

Athanasia Alexoudi; Vincenzo Donadio; Elissaios Karageorgiou

doi:10.3389/fnins.2024.1479830

The potential role of CGRP in synuclein-associated neurodegenerative disorders

Front Neurosci. 2024 Nov 6:18:1479830. doi: 10.3389/fnins.2024.1479830. eCollection 2024.

Authors

Athanasia Alexoudi¹, Vincenzo Donadio², Elissaios Karageorgiou¹

Affiliations

¹ Neurological Institute of Athens, Athens, Greece.
² IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.

Abstract

In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of α-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.

Keywords: CGRP; GLP-1; apoptosis; neuroinflammation; neuromodulation; synuclein-associated neurodegenerative disorders.

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by an ACSF-22-971298 fellowship grant to Athanasia Alexoudi and the Horizon 2020 program (No 965422) on Multidisciplinary Expert System for the Assessment and Management of Complex Brain Disorders.