Aim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of articles, patents and clinical trials on trans-chalcone's applications and biological activities.Areas covered: The review proposed a thorough analysis of studies such as scientific articles, patents and clinical studies related to the topic. The searches were carried out in their respective databases and analyzed through the exclusion steps, until selecting studies that corroborate the importance of the topic. The review consolidated evidence from multiple studies, encompassing in vitro and in vivo methodologies across different conditions like cancer, leishmania, skin protection, inflammation and metabolic diseases.Expert opinion: Patent analysis indicated growing interest from pharmaceutical companies and universities, suggesting diverse applications from chronic diseases to previously challenging conditions. Clinical trials utilizing trans-chalcone revealed insufficient investigation, crucial for obtaining essential pharmacokinetic and pharmacodynamic data. While positive results were noted, the review also identified knowledge gaps and areas needing further exploration. In summary, trans-chalcone holds promise for new therapies, supported by evidence from patents, clinical trials and systematic reviews, driving continued research and development in this field.
Keywords: clinical trials; flavonoids; patents; pharmacology activities; systematic review; trans-chalcone.
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