Genome sequencing of 'Fuji' apple clonal varieties reveals genetic mechanism of the spur-type morphology

Nat Commun. 2024 Nov 21;15(1):10082. doi: 10.1038/s41467-024-54428-2.

Abstract

Somatic variations can give rise to bud sports with advantageous traits, serving as the foundation for bud sport breeding in perennial plants. Here, we report a fully phased genome assembly of 'Fuji' apple, enabling comprehensive identification of somatic variants across 74 clonally propagated 'Fuji' varieties. Phylogenetic analysis indicates that spur-type and early-maturation traits in 'Fuji' sport varieties arise from multiple independent events. Several putative functional somatic variants have been identified, including a spur-type-specific deletion in the promoter of the TCP transcription factor gene MdTCP11. DNA methylation level of the deletion-associated miniature inverted-repeat transposable element is lower in spur-type varieties compared to standard-type varieties, while the expression of MdTCP11 is significantly higher. Overexpression of MdTCP11 in apple decreases plant height, highlighting its important role in the development of spur-type apple varieties. This study sheds light on the cloning history of 'Fuji' and provides valuable resources for apple breeding.

MeSH terms

  • DNA Methylation / genetics
  • DNA Transposable Elements / genetics
  • Gene Expression Regulation, Plant
  • Genome, Plant*
  • Malus* / genetics
  • Phylogeny*
  • Plant Breeding / methods
  • Plant Proteins* / genetics
  • Plant Proteins* / metabolism
  • Plants, Genetically Modified / genetics
  • Promoter Regions, Genetic / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Plant Proteins
  • Transcription Factors
  • DNA Transposable Elements