Application of the LADA Strategy for the Synthesis of Styrylalanine through Photocatalytic Addition to Alkenylboronic Acids

Org Lett. 2024 Dec 6;26(48):10299-10302. doi: 10.1021/acs.orglett.4c03848. Epub 2024 Nov 24.

Abstract

Unnatural amino acids (UAAs) are highly valuable building blocks in organic synthesis, pharmaceuticals, and material sciences. Previously, we developed the LADA strategy for the synthesis of UAAs. Herein, we further expanded the scope of this strategy to alkenylboronic acids. Interestingly, both photoinduced single-electron transfer (SET) and energy transfer (EnT) processes were involved in this reaction, and the E/Z ratio of the products could be changed upon reaction condition.