Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis

Andre Jove; Christina Lin; Joo Ha Hwang; Vidhya Balasubramanian; Nielsen Q Fernandez-Becker; Robert J Huang

doi:10.14309/ajg.0000000000003235

Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis

Am J Gastroenterol. 2024 Nov 26. doi: 10.14309/ajg.0000000000003235. Online ahead of print.

Authors

Andre Jove¹, Christina Lin², Joo Ha Hwang², Vidhya Balasubramanian¹, Nielsen Q Fernandez-Becker², Robert J Huang²

Affiliations

¹ Department of Medicine, Stanford University, Stanford, California, USA.
² Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA .

PMID: 39588964
DOI: 10.14309/ajg.0000000000003235

Abstract

Introduction: Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk.

Methods: We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET.

Results: We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET.

Discussion: Gastrin levels differ significantly between patients with AMAG with and without gNET.