IMPACT OF NIRSEVIMAB ON RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN HOSPITALIZED INFANTS: A REAL-WORLD STUDY

Eric Jeziorski; Antoine Ouziel; Marie Cotillon; Constance Bridonneau; Etienne Bizot; Clément Basse; Aurélie Portefaix; François Dubos; Stéphane Béchet; Lea Domitien; Carine Jaillet; Sorin Abrudan; Rolf Kramer; Vincent Gajdos; Elise Launay; Romain Basmaci; Yves Gillet; Robert Cohen; Corinne Levy

doi:10.1097/INF.0000000000004630

IMPACT OF NIRSEVIMAB ON RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN HOSPITALIZED INFANTS: A REAL-WORLD STUDY

Pediatr Infect Dis J. 2024 Nov 26. doi: 10.1097/INF.0000000000004630. Online ahead of print.

Authors

Eric Jeziorski^{1

2}, Antoine Ouziel^{1

3}, Marie Cotillon^{1

4}, Constance Bridonneau⁵, Etienne Bizot^{1

6}, Clément Basse⁷, Aurélie Portefaix⁸, François Dubos⁹, Stéphane Béchet¹⁰, Lea Domitien², Carine Jaillet², Sorin Abrudan¹¹, Rolf Kramer¹¹, Vincent Gajdos^{1

6}, Elise Launay^{1

5}, Romain Basmaci^{1

4

12}, Yves Gillet^{1

3}, Robert Cohen^{1

10

13

9}, Corinne Levy^{1

10

13

9}

Affiliations

¹ Groupe de Pathologie Infectieuse Pediatrique (GPIP), Creteil.
² Service urgences post-urgences pédiatriques, PCCEI, Univ Montpellier, CHU Montpellier, Montpellier.
³ Urgences pédiatriques, Hôpital Femme Mère Enfant Service des Urgences Pédiatriques, Bron.
⁴ Service de pédiatrie-urgence, Hôpital Louis Mourier, Colombes.
⁵ Médecine pédiatrique, Hôpital enfant-adolescent-CHU de Nantes, Nantes.
⁶ Pédiatrie générale et Urgences pédiatriques, Hôpital Antoine-Béclère AP-HP, Clamart.
⁷ Urgences pédiatriques, Hôpital Salengro, CHU Lille, Lille.
⁸ Centre d'Investigation Clinique, Hospices Civils de Lyon-HCL, Lyon.
⁹ Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France.
¹⁰ Association Clinique et Thérapeutique Infantile du Val-de-Marne France (ACTIV), Créteil.
¹¹ Sanofi Vaccines, Lyon.
¹² Université Paris Cité, Inserm, IAME, Paris.
¹³ Université Paris Est, IMRB-GRC GEMINI.

PMID: 39589139
DOI: 10.1097/INF.0000000000004630

Abstract

Regarding nirsevimab immunization status, among 1085 infants hospitalized for bronchiolitis, the odds of hospitalization for respiratory syncytial virus bronchiolitis were 4.7 times higher for nonimmunized children. Immunized infants were less likely to require oxygen supplementation (20.2% vs. 30.6%, P = 0.02) and had a 1-day shorter hospital stay. Respiratory syncytial virus bronchiolitis was less frequent and less severe in infants immunized with nirsevimab.