New diketopiperazine dimers and 4-hydroxyphenylacetates from an endolichenic fungus Aspergillus sp

Bingjie Su; Tao Zhang; Mengjia Mao; Renzhong Wang; Baoqing You; Jing Zhang; Liyan Yu; Shuyi Si; Jingshuai Wu; Minghua Chen

doi:10.1016/j.fitote.2024.106318

New diketopiperazine dimers and 4-hydroxyphenylacetates from an endolichenic fungus Aspergillus sp

Fitoterapia. 2024 Nov 27:180:106318. doi: 10.1016/j.fitote.2024.106318. Online ahead of print.

Authors

Affiliations

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
² Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: [email protected].
³ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang Uygur Autonomous Region, Urumqi 830004, China. Electronic address: [email protected].

PMID: 39608465
DOI: 10.1016/j.fitote.2024.106318

Abstract

Two novel diketopiperazine dimers (1 and 2) and two new 4-hydroxyphenylacetates (5 and 6), along with two previously known diketopiperazine dimers were isolated from the culture of the endolichenic fungus Aspergillus sp. CPCC 400810. Their structures were determined through comprehensive spectroscopic analysis, including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) data. The absolute configurations of the new compounds were confirmed using Marfey's method and chemical synthesis.

Keywords: 4-hydroxyphenylacetates; Aspergillus; Diketopiperazine dimers; Endolichenic fungi.