The Unusual Clinical Presentation of Eosinophilic Gastroenteritis and Its Response to Mepolizumab: Two Case Reports

Eosinophilic gastroenteritis (EGE) is a rare digestive disorder that affects individuals of all ages, characterized by eosinophilic infiltration in the stomach and intestines. Various risk factors contribute to EGE, and its pathogenesis remains poorly understood. The definitive diagnosis relies on histological examination of the involved gastrointestinal (GI) tract, revealing evidence of eosinophilic infiltration. We present two case reports of young males diagnosed with EGE who achieved good outcomes with early management, including steroids and mepolizumab. The use of a biologic agent, anti-IL5, helped reduce the use of steroids and both patients were in complete remission based on GI symptom assessments. The clinical presentation of EGE is non-specific, which can make diagnosis challenging. Currently, there is no definitive consensus on the optimal treatment for EGE, and management remains primarily empirical. Limited data are available on EGE, and these cases may help provide additional insights into the diagnosis and management of this rare disease.