The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

Objective: Previous studies on the link between VEGF gene polymorphisms and bronchopulmonary dysplasia (BPD) have yielded inconsistent results. This meta-analysis sought to clarify the relationship between genetic variations in the VEGF gene and the risk of BPD.

Methods: Data were collected from multiple databases, including PubMed, Scopus, EMBASE, and CNKI, up to January 5, 2024.

Results: Nineteen case-control studies were analyzed, featuring 1,051 BPD cases and 1,726 healthy neonates. The analysis included four studies on the -460T/C polymorphism (312 cases, 536 controls), four on the -2578C/A polymorphism (155 cases, 279 controls), six on the +405G/C polymorphism (329 cases, 385 controls), and five on the +936C/T polymorphism (225 cases, 526 controls). The meta-analysis suggests that the -460T/C polymorphism may protect against BPD (C vs. T: OR = 0.715, 95% CI 0.543-0.941, p = 0.017; CC vs. TT: OR = 0.478, 95% CI 0.233-0.983, p = 0.045; CC vs. CT + TT: OR = 0.435, 95% CI 0.248-0.764, p = 0.004). No significant associations were found between the -2578C/A, +405G/C, and +936C/T polymorphisms and BPD susceptibility.

Conclusions: This meta-analysis indicates that the C allele of the -460T/C polymorphism may offer protection against BPD. No significant associations were observed for the -2578C/A, +405G/C, and +936C/T polymorphisms.