Inter-membrane control of junctional InsP3 receptors by PIP2

Yandong Zhou; Youjun Wang; Donald L Gill

doi:10.1016/j.tcb.2024.11.004

Inter-membrane control of junctional InsP₃ receptors by PIP₂

Trends Cell Biol. 2025 Jan;35(1):1-3. doi: 10.1016/j.tcb.2024.11.004. Epub 2024 Nov 29.

Authors

Yandong Zhou¹, Youjun Wang², Donald L Gill³

Affiliations

¹ Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: [email protected].
² Beijing Key Laboratory of Gene Resources and Molecular Development College of Life Sciences, Beijing Normal University, Beijing 100875, PR China. Electronic address: [email protected].
³ Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: [email protected].

PMID: 39613531
PMCID: PMC11698628 (available on 2026-01-01)
DOI: 10.1016/j.tcb.2024.11.004

Abstract

Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca²⁺ signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP₂) reaches across plasma membrane (PM)-endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca²⁺ signals mediating a spectrum of fundamental cellular responses.

Keywords: calcium signals; inositol trisphosphate receptors; phosphatidylinositol bisphosphate.

Publication types

Review

MeSH terms

Animals
Calcium / metabolism
Calcium Signaling
Cell Membrane* / metabolism
Endoplasmic Reticulum / metabolism
Humans
Inositol 1,4,5-Trisphosphate Receptors* / metabolism
Phosphatidylinositol 4,5-Diphosphate* / metabolism

Substances

Phosphatidylinositol 4,5-Diphosphate
Inositol 1,4,5-Trisphosphate Receptors
Calcium

Grants and funding

R35 GM153379/GM/NIGMS NIH HHS/United States