Historical plague pandemics: perspectives from ancient DNA

Trends Microbiol. 2025 Jan;33(1):7-10. doi: 10.1016/j.tim.2024.10.008. Epub 2024 Nov 29.

Abstract

Ancient DNA research has provided important insights into the evolutionary history of Yersinia pestis during the historical plague pandemics. Future work should prioritise a more diversified approach to sampling, to ensure a broader understanding of the factors underlying pandemic onset, spread, and impact across different regions and hosts.

Keywords: Black Death; Justinianic Plague; Yersinia pestis; ancient pathogen genomics; pathogen evolution.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • DNA, Ancient* / analysis
  • DNA, Bacterial / genetics
  • Evolution, Molecular
  • History, Ancient
  • Humans
  • Pandemics* / history
  • Plague* / epidemiology
  • Plague* / history
  • Plague* / microbiology
  • Yersinia pestis* / genetics

Substances

  • DNA, Ancient
  • DNA, Bacterial