Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α

J Clin Invest. 2024 Dec 2;134(23):e185569. doi: 10.1172/JCI185569.

Hong Wang^{1

2

3}, Maria Miranda^{1

2

3}, Eizo Marutani⁴, Paul Lichtenegger⁴, Gregory R Wojtkiewicz⁵, Fumito Ichinose⁴, Vamsi K Mootha^{1

2

3}

¹ Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
² Broad Institute, Cambridge, Massachusetts, USA.
³ Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
⁴ Anesthesia Center for Critical Care Research and.
⁵ Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

No abstract available

Keywords: Genetics; Hypoxia.