Introducing all-inkjet-printed microneedles for in-vivo biosensing

Giulio Rosati; Patricia Batista Deroco; Matheus Guitti Bonando; Gustavo G Dalkiranis; Kumara Cordero-Edwards; Gabriel Maroli; Lauro Tatsuo Kubota; Osvaldo N Oliveira Jr; Lúcia Akemi Miyazato Saito; Cecilia de Carvalho Castro Silva; Arben Merkoçi

doi:10.1038/s41598-024-80840-1

Introducing all-inkjet-printed microneedles for in-vivo biosensing

Sci Rep. 2024 Dec 2;14(1):29975. doi: 10.1038/s41598-024-80840-1.

Authors

Giulio Rosati^#¹, Patricia Batista Deroco^#^{2

3

4}, Matheus Guitti Bonando^#^{2

5

6}, Gustavo G Dalkiranis^{2

7}, Kumara Cordero-Edwards², Gabriel Maroli^{2

8}, Lauro Tatsuo Kubota^{3

4}, Osvaldo N Oliveira Jr⁷, Lúcia Akemi Miyazato Saito^{5

6}, Cecilia de Carvalho Castro Silva^{5

6}, Arben Merkoçi^{9

10}

Affiliations

¹ Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193, Bellaterra, Barcelona, Spain. [email protected].
² Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193, Bellaterra, Barcelona, Spain.
³ Institute of Chemistry, University of Campinas - UNICAMP, Campinas, 13083-970, Brazil.
⁴ National Institute of Science and Technology in Bioanalytic (INCTBio), Campinas, 13083-970, Brazil.
⁵ School of Engineering, Mackenzie Presbyterian University, Rua da Consolação, 930, Sao Paulo, SP, 01302-907, Brazil.
⁶ MackGraphe - Mackenzie Institute for Research in Graphene and Nanotechnologies, Rua da Consolação, 930, Sao Paulo, SP, 01302-907, Brazil.
⁷ São Carlos Institute of Physics, University of São Paulo, P.O. Box 369, São Carlos, SP, 13560-970, Brazil.
⁸ Instituto de Investigaciones en Ingeniería Eléctrica Alfredo Desages (IIIE), Universidad Nacional del Sur, CONICET, Avenida Colón 80, Bahía Blanca, Buenos Aires, Argentina.
⁹ Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193, Bellaterra, Barcelona, Spain. [email protected].
¹⁰ ICREA, Passeig Lluís Companys 23, 08010, Barcelona, Spain. [email protected].

^# Contributed equally.

Abstract

Microneedles are mainly used for pain-free drug administration and in biosensing for wearable systems. They are also promising for fields such as agronomy for precision farming, but their fabrication is not straightforward, often requiring expensive equipment and cleanroom protocols, being unsuitable for mass production. Here, we report a new and simple method for the scalable fabrication of all-inkjet-printed conductive microneedles based on silver nanoparticles (extensible to any other metallic nanoparticle ink) and a simple example of their application for monitoring the electrochemical properties of plants.

Keywords: EIS; Inkjet printing; Microneedles; Plants; Precision agriculture; Silver nanoparticles.

MeSH terms

Biosensing Techniques* / instrumentation
Biosensing Techniques* / methods
Ink
Metal Nanoparticles* / chemistry
Needles*
Printing
Silver* / chemistry

Substances

Silver