Pyroptosis, apoptosis, and necroptosis are three key types of pathways in programmed cell death (PCD). Studies have found a wide range of cross-talk between the three types of pathways, leading to the proposal of the concept of PANoptosis, or the inflammatory PCD pathway regulated by the PANoptosome complex, which has key features of pyroptosis, apoptosis, and/or necroptosis that cannot be explained by any of these single pathways. A growing number of studies have discovered that PANoptosis is involved in many liver-related disease processes, including liver cancer, metabolic-associated fatty liver disease, liver failure, fulminant viral hepatitis, and others. Therefore, this paper reviews the potential mechanism and role of PANoptosis in order to provide directions for studying the pathogenesis and potential therapeutic strategies for a variety of liver-related diseases.
细胞焦亡、细胞凋亡、坏死性凋亡是3种关键的程序性细胞死亡（PCD）通路。研究发现3条通路间存在广泛的相互串扰现象，并提出了泛凋亡（PANoptosis）概念，即由泛凋亡体（PANoptosome）复合物调节的炎症性PCD通路，有焦亡、细胞凋亡和/或坏死性凋亡的关键特征，这些特征不能单独由这些PCD通路中的任何一种机制来解释。越来越多的研究发现泛凋亡参与许多肝脏相关疾病过程，包括肝癌、代谢相关脂肪性肝病、肝衰竭、病毒性暴发性肝炎等。因此，现就泛凋亡的潜在机制以及泛凋亡在不同肝脏疾病中的作用及其机制进行综述，为多种肝脏相关疾病发病机制的研究与潜在治疗策略提供方向。.