Abstract
ABSTRACTThe current outbreak of HPAI H5N1 virus infections in dairy cattle in the USA underscores the need for easily accessible methods to rapidly assess host susceptibility for infection with known and emerging influenza viruses. Here we show that ex vivo lung slice cultures from calves provide a useful method to rapidly screen host susceptibility to a range of influenza A viruses.
Keywords:
HPAI H5N1; Influenza; cattle; lung slices; species susceptibility.
MeSH terms
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Animals
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Cattle
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Cattle Diseases / epidemiology
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Cattle Diseases / virology
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Disease Susceptibility
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Influenza A Virus, H5N1 Subtype* / genetics
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Influenza A Virus, H5N1 Subtype* / pathogenicity
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Influenza A Virus, H5N1 Subtype* / physiology
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Lung* / virology
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Orthomyxoviridae Infections* / veterinary
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Orthomyxoviridae Infections* / virology
Grants and funding
This work was supported by Deutsche Forschungsgemeinschaft ; Open Access Publication Fund of the University of Veterinary Medicine Hannover.