Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM

Ivan Luiz Padilha Bonfante; Higor da Silva Segantim; Kauê Neto Soares Mendonça; Murilo Augusto Belmiro de Oliveira; Milena Monfort-Pires; Renata Garbellini Duft; Keryma Chaves da Silva Mateus; Mara Patricia Traina Chacon-Mikahil; Celso Darío Ramos; Licio Augusto Velloso; Cláudia Regina Cavaglieri

doi:10.1007/s12020-024-04122-6

Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM

Endocrine. 2024 Dec 3. doi: 10.1007/s12020-024-04122-6. Online ahead of print.

Authors

Ivan Luiz Padilha Bonfante^{1

2}, Higor da Silva Segantim^#³, Kauê Neto Soares Mendonça^#³, Murilo Augusto Belmiro de Oliveira^#³, Milena Monfort-Pires^{4

5

6}, Renata Garbellini Duft^{7

8}, Keryma Chaves da Silva Mateus⁷, Mara Patricia Traina Chacon-Mikahil⁷, Celso Darío Ramos⁹, Licio Augusto Velloso^{4

5}, Cláudia Regina Cavaglieri⁷

Affiliations

¹ Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil. [email protected].
² Postdoctoral Researcher Program (PPPD), University of Campinas, Campinas, Brazil. [email protected].
³ Higher Interdisciplinary Training Program (PROFIS), University of Campinas, Campinas, SP, Brazil.
⁴ Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
⁵ Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, Brazil.
⁶ Turku Pet Centre, University of Turku, Turku, Finland.
⁷ Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.
⁸ The Rowett Institute of Nutrition and Health, University of Aberdeen, Ashgrove Rd W, Aberdeen, Scotland, UK.
⁹ Department of Radiology, University of Campinas, Campinas, SP, Brazil.

^# Contributed equally.

PMID: 39627400
DOI: 10.1007/s12020-024-04122-6

Abstract

Purpose: Brown adipose tissue (BAT), located in the supraclavicular region, has been associated with a better cardiometabolic profile and reduced risk of developing non-communicable chronic diseases (NCD), in addition to being associated with a healthier phenotype in obesity. However, it is unknown whether greater supraclavicular adipose tissue activity could be associated with a healthier metabolic profile in people already diagnosed with type 2 diabetes (T2DM). Thus, the present work evaluated if supraclavicular adipose tissue activity is associated with metabolic and molecular markers in individuals with T2DM.

Methods: Based on a cluster study, individuals with T2DM were divided into groups according to high or low-standard uptake value (SUV) evaluated in the supraclavicular adipose tissue area by [18F]-fluorodeoxyglucose and positron emission tomography-computed tomography (¹⁸F-FDG-PET/CT) after mild cold exposure). Functional, biochemical, inflammatory, and molecular markers were measured.

Results: When we evaluated the whole sample, women showed higher SUV, which favored a difference between groups in sex-related markers. On the other hand, volunteers in the high-SUV group showed lower BMI, monocytes count, triglycerides/glucose index (TYG-index) and z score of metabolic syndrome (MS) values, as well as lower triglycerides, and VLDL concentrations. Moreover, they also had enhanced expression of thermogenic genes in subcutaneous fat. When analyzing only women, the differences in markers associated with sex disappear, and a lower count of leukocytes, platelets, along with lower TYG-index, z score of MS values, and triglycerides, VLDL, LDL, and TNFα concentrations were observed in women with the high SUV. In addition, higher expression of thermogenic genes and BECN1 were detected.

Conclusion: Higher supraclavicular adipose tissue SUV in individuals with T2DM is associated with a better cardiometabolic/inflammatory profile and expression of thermogenic genes.

Clinical trial registration: UTN: U1111-1202-1476 - 08/20/2020.

Keywords: Beige adipose tissue; Brown adipose tissue; Metabolism; Overweight; Thermogenesis; Type 2 diabetes.

Abstract

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