Regio- and Stereoselective β-Sulfonylamination of Alkynes via Photosensitized Bifunctional N-S Bond Homolysis

Org Lett. 2024 Dec 13;26(49):10604-10610. doi: 10.1021/acs.orglett.4c04091. Epub 2024 Dec 4.

Abstract

Nitrogen central radicals (NCRs) are versatile synthetic intermediates for creating functional nitrogen-containing molecules. Herein, a photosensitized β-sulfonylamination of terminal alkynes as well as acetylene has been established by employing N-sulfonyl heteroaromatics as bifunctional reagents (BFRs) to efficiently deliver versatile (E)-β-sulfonylvinylamines with excellent regio- and stereoselectivities. Mechanistic studies suggest a base-accelerated energy transfer (EnT) photocatalysis involving aromatic NCR formation, radical addition to alkynes, and sulfonylation processes.