Abstract
Diabetes-induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by cognitive impairment driven by neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of the X-linked inhibitor of apoptosis protein (XIAP)/thioredoxin-interacting protein (TXNIP) in hippocampal neuron cell death and cognitive function within DCD models. A diabetic rat model was established using a high-fat/sucrose diet and streptozotocin injection. Primary hippocampal neurons were stimulated with HG to mimic diabetic conditions. Cognitive and memory functions were assessed using the Morris water maze (MWM) and novel object recognition test (ORT).
Keywords:
TXNIP; XIAP; diabetes‐induced cognitive dysfunction; endoplasmic reticulum stress.
© 2024 The Author(s). The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University.
MeSH terms
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Animals
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Carrier Proteins* / metabolism
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Cell Cycle Proteins
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Cognitive Dysfunction* / etiology
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Cognitive Dysfunction* / metabolism
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Cognitive Dysfunction* / pathology
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Diabetes Mellitus, Experimental* / complications
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Diabetes Mellitus, Experimental* / metabolism
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Diet, High-Fat / adverse effects
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Glucose / metabolism
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Glucose / pharmacology
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Hippocampus* / metabolism
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Hippocampus* / pathology
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Inhibitor of Apoptosis Proteins
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Male
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Neurons* / drug effects
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Neurons* / metabolism
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Neurons* / pathology
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Rats
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Rats, Sprague-Dawley
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Streptozocin / toxicity
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism
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Ubiquitination / drug effects
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X-Linked Inhibitor of Apoptosis Protein / genetics
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X-Linked Inhibitor of Apoptosis Protein / metabolism
Substances
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TXNIP protein, rat
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Carrier Proteins
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Xiap protein, rat
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X-Linked Inhibitor of Apoptosis Protein
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Streptozocin
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Ubiquitin-Protein Ligases
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Glucose
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Cell Cycle Proteins
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Inhibitor of Apoptosis Proteins