Many dermatologic medications have the potential to induce ocular complications. Traditional medications, including corticosteroids, retinoids, antibiotics, antihistamines, and immunosuppressants, have been associated with eye dryness, irritation, allergy, infection, atrophy, pigmentary changes, increased intraocular pressure, and impaired vision. Novel therapeutic agents such as biologics raise new concerns for ocular surface disease and conjunctivitis. Dermatologists should recognize these oculocutaneous side effects for appropriate decision-making, coordinating interdisciplinary care, and optimizing patient outcomes. J Drugs Dermatol. 2024;23(12):1108-1113. doi:10.36849/JDD.8236.