Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Takuya Fujimoto; Tooru Andoh; Tamotsu Sudo; Ikuo Fujita; Yoshinori Sakurai; Takushi Takata; Hiroki Tanaka; Teruya Kawamoto; Shunsuke Yahiro; Shotaro Nakamura; Hitomi Hara; Naomasa Fukase; Toshihiro Akisue; Hideki Ichikawa; Ryosuke Kuroda; Minoru Suzuki

doi:10.1016/j.apradiso.2024.111603

Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Appl Radiat Isot. 2024 Nov 26:217:111603. doi: 10.1016/j.apradiso.2024.111603. Online ahead of print.

Authors

Affiliations

¹ Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi, 673-8558, Japan. Electronic address: [email protected].
² Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, 650-8586, Japan.
³ Department of Genomic Medicine, Fujita Health University, Toyoake, 470-1192, Japan.
⁴ Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi, 673-8558, Japan.
⁵ Institute for Integrated Radiation and Nuclear Science, Kyoto University, Sennan-gun, 590-0494, Japan.
⁶ Department of Orthopaedic Surgery, Konan Medical Center, Kobe, 658-0064, Japan.
⁷ Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
⁸ Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan; Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, 654-0142, Japan.

PMID: 39632319
DOI: 10.1016/j.apradiso.2024.111603

Abstract

Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.

Keywords: Boron neutron capture therapy (BNCT); Cell line; Myxofibrosarcoma; p-borono-(L)-phenylalanine ((L)-BPA).