Biocompatible hydrogel coating on single living cells through visible light-induced polymerization

Chem Commun (Camb). 2024 Dec 19;61(2):322-325. doi: 10.1039/d4cc03075c.

Abstract

Visible light-mediated photocatalysis leads to the efficient hydrogel coating of individual mammalian cells, functionalized with biocompatible anchor molecules tagged with fluorescein serving as a trifecta: photocatalyst, initiator, and fluorophore. NIH3T3 fibroblast cells are encapsulated within hydrogel shells of poly(ethylene glycol) diacrylate (PEGDA) and N-vinylpyrrolidone without any noticeable decrease in cell viability.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Catalysis
  • Cell Survival* / drug effects
  • Hydrogels* / chemistry
  • Light*
  • Mice
  • NIH 3T3 Cells
  • Photochemical Processes
  • Polyethylene Glycols* / chemistry
  • Polymerization*
  • Pyrrolidinones / chemistry

Substances

  • Polyethylene Glycols
  • Hydrogels
  • poly(ethylene glycol)diacrylate
  • Biocompatible Materials
  • Pyrrolidinones
  • N-vinyl-2-pyrrolidinone