Flow synthesis and multidimensional parameter screening enables exploration and optimization of copper oxide nanoparticle synthesis

Copper-based nanoparticles (NPs) are highly valued for their wide-ranging applications, with particular significance in CO₂ reduction. However current synthesis methods encounter challenges in scalability, batch-to-batch variation, and high energy costs. In this work, we describe a novel continuous flow synthesis approach performed at room temperature to help address these issues, producing spherical, colloidally stable copper(ii) oxide (CuO) NPs. This approach leverages stabilizing ligands like oleic acid, oleylamine, and soy-lecithin, a novel choice for CuO NPs. The automated flow platform facilitates facile, real-time parameter screening of Cu-based nanomaterials using optical spectroscopy, achieving rapid optimization of NP properties including size, size dispersity, and colloidal stability through tuning of reaction parameters. This study highlights the potential of continuous flow synthesis for efficient parameter exploration to accelerate understanding, optimization, and eventually enable scale-up of copper-based NPs. This promises significant benefits for various sectors, including energy, healthcare, and environmental conservation, by enabling reliable production with reduced energy and cost requirements.