A case of adult ETV6-ASCL6 fusion gene positive chronic myeloproliferative tumor and literature review

Wei-Ge Xu; Pei Wang; Yan-Min Yang; Xian-Hua Yuan

doi:10.12669/pjms.40.11.8556

A case of adult ETV6-ASCL6 fusion gene positive chronic myeloproliferative tumor and literature review

Pak J Med Sci. 2024 Dec;40(11):2759-2762. doi: 10.12669/pjms.40.11.8556.

Authors

Wei-Ge Xu¹, Pei Wang², Yan-Min Yang³, Xian-Hua Yuan⁴

Affiliations

¹ Wei-ge Xu Department of Hematology, First Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China.
² Pei Wang Department of Hematology, First Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China.
³ Yan-min Yang Department of Hematology, First Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China.
⁴ Xian-hua Yuan Vice President, First Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China.

Abstract

ETV6-ASCL6 fusion gene plays an important role in hematopoiesis and hematological malignancies, but it is rare in hematological diseases. This paper describes a case of etv6-ascl6 fusion gene positive patient who was successively diagnosed as myelofibrosis, eosinophilic leukemia, basophilic leukemia and secondary acute myeloid leukemia. The clinical manifestations and disease evolution have its unique characteristics.

Keywords: ETV6-ASCL6; Myeloproliferative tumor; Positive chronic.

Publication types

Case Reports