Host-in-Host Complexation: Activating Classical Hosts through Complete Encapsulation within an M9L6 Coordination Cage

Kenta Iizuka; Hiroki Takezawa; Makoto Fujita

doi:10.1002/anie.202422143

Host-in-Host Complexation: Activating Classical Hosts through Complete Encapsulation within an M₉L₆ Coordination Cage

Angew Chem Int Ed Engl. 2024 Dec 5:e202422143. doi: 10.1002/anie.202422143. Online ahead of print.

Authors

Kenta Iizuka¹, Hiroki Takezawa¹, Makoto Fujita^{2

3}

Affiliations

¹ Department of Applied Chemistry, School of Engineering, The University of Tokyo, Mitsui Link Lab Kashiwanoha 1, FS CREATION, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
² Tokyo Colledge, UT Institutes for Advanced Study, The University of Tokyo, Mitsui Link Lab Kashiwanoha 1, FS CREATION, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
³ Division of Advanced Molecular Science, Institute for Molecular Science (IMS), 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.

PMID: 39635831
DOI: 10.1002/anie.202422143

Abstract

This study reports a method for enhancing the functions and properties of traditional organic macrocyclic hosts by fully encapsulating them within a large M₉L₆ cage to form host-in-host complexes. Within the cage host, the macrocyclic organic hosts with electron-rich aromatic rings, such as cyclotriveratrylene and calix[8]arene, adopt specific orientations enhancing their inherent molecular recognition abilities. Due to the high crystallinity of the M₉L₆ cage, the guest encapsulation behavior of the host-in-host complexes can be observed by X-ray structural analysis.

Keywords: Host-guest; Inclusion compound; Macrocycle; Molecular recognition; Self-assembly.

Abstract

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