Rewiring of the glymphatic landscape in metabolic disorders

Bandy Chen; David Meseguer; Stephanie Lenck; Jean-Leon Thomas; Marc Schneeberger

doi:10.1016/j.tem.2024.11.005

Rewiring of the glymphatic landscape in metabolic disorders

Trends Endocrinol Metab. 2024 Dec 4:S1043-2760(24)00295-9. doi: 10.1016/j.tem.2024.11.005. Online ahead of print.

Authors

Bandy Chen¹, David Meseguer², Stephanie Lenck³, Jean-Leon Thomas⁴, Marc Schneeberger⁵

Affiliations

¹ Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. Electronic address: [email protected].
² Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
³ Department of Neuroradiology, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France; Institut du Cerveau, Pitié-Salpêtrière Hospital, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Paris, France.
⁴ Institut du Cerveau, Pitié-Salpêtrière Hospital, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Paris, France; Department of Neurology, Yale School of Medicine, New Haven, CT, USA. Electronic address: [email protected].
⁵ Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Wu Tsai Institute for Mind and Brain, Yale University, New Haven, CT, USA. Electronic address: [email protected].

PMID: 39638721
DOI: 10.1016/j.tem.2024.11.005

Abstract

The incorporation of the glymphatic clearance system in the study of brain physiology aids in the advancement of innovative diagnostic and treatment strategies for neurological disorders. Exploring the glymphatic system across (from) neurological and (to) metabolic diseases may provide a better link between obesity and neurological disorders. Recent studies indicate the role of metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through the disruption of the glymphatic system. Further investigation into how metabolic dysfunction disrupts glymphatic homeostasis and the domino effects on the neurovascular landscape, including neurovascular uncoupling, cerebral blood flow disruptions, blood-brain barrier leakage, and demyelination, can provide mechanistic insights into the link between obesity and neurological disorders.

Keywords: cerebral blood flow; cerebrospinal fluid; glymphatic system; metabolic syndrome; neurodegeneration; obesity.

Publication types

Review