Silent silencers: Leave no trace

Mol Cell. 2024 Dec 5;84(23):4473-4475. doi: 10.1016/j.molcel.2024.11.005.

Abstract

The regulatory mechanisms of silencers have remained poorly understood. In this issue, Hofbauer et al.1 conduct a genome-wide screen in Drosophila melanogaster and reveal three silencer types that appear to work alone-without the need for combinatorial action, traditional chromatin marks, or open chromatin regions.

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster* / genetics
  • Gene Silencing

Substances

  • Chromatin
  • Drosophila Proteins