Let's (P-s)talk about specialized ribosomes

Robert F Harvey; Tuija Pöyry; Anne E Willis

doi:10.1016/j.molcel.2024.11.011

Let's (P-s)talk about specialized ribosomes

Mol Cell. 2024 Dec 5;84(23):4478-4479. doi: 10.1016/j.molcel.2024.11.011.

Authors

Robert F Harvey¹, Tuija Pöyry¹, Anne E Willis²

Affiliations

¹ MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
² MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. Electronic address: [email protected].

PMID: 39642853
DOI: 10.1016/j.molcel.2024.11.011

Abstract

In a recent study in Cell, Dopler et al.¹ show that a subpopulation of P-stalk-containing ribosomes (PSRs) are generated following exposure to cytokines, and the data suggest that PSRs are central mediators of translational reprogramming during the cytokine- and immune-response.

MeSH terms

Animals
Cytokines / metabolism
Humans
Protein Biosynthesis*
Ribosomal Proteins / genetics
Ribosomal Proteins / metabolism
Ribosomes* / genetics
Ribosomes* / metabolism

Substances

Cytokines
Ribosomal Proteins