Three species are recorded from Panama for the first time: Lagocheirus cristulatus Bates, 1872; Leptostylus guianensis Vlasak & Santos-Silva, 2021; and Nealcidion cephaliferum Vlasak & Santos-Silva, 2022. Lepturges (Lepturges) brechlini Santos-Silva et al., 2019 is synonymized with L. (L.) vigneaulti Audureau, 2018. Three new species are described from Panama: Pseudosparna rileyi sp. nov. (Acanthocinini); Sternacutus cupelloi sp. nov. (Acanthocinini); and Antodice raberi sp. nov. (Aerenicini). An updated key to species of Pseudosparna Mermudes & Monné, 2009 is provided.