A scoping review and hypothetical framework about the interplay between oxytocin and eating disorders

Introduction: Despite emerging evidence on oxytocin's role in eating disorders,there is a need for a comprehensive review to integrate findings across neurobiological, genetic, hormonal, and therapeutic dimensions. This scoping review synthesizes existing literature on OXT's role in EDs and proposes a new theoretical perspective based on diverse research findings.

Methods: In accordance with PRISMA guidelines, we systematically synthesized all peer-reviewed articles indexed on PubMed which focused on both OXT and EDs as of December 2023 (k = 32 studies, n = 1942 participants). After summarizing this literature in tables, we completed the narrative synthesis with a discussion of mechanisms informed by an unstructured literature review.

Results: The existing studies propose a connection between OXT receptor Oxtr polymorphisms and ED diagnoses, severity of symptoms, macronutrient preferences, reward function, and early life stress. In addition, OXT plasma levels normalized with ED symptom reduction. Although some OXT studies have failed to show therapeutic changes in food intake and weight, few have reported ameliorations in brain function, food-related attentional bias, cognition, and emotional regulation. Some data have also suggested a contributory role of the transforming growth factor β (TGFβ) and sterol regulatory element binding proteins (SREBPs) to the etiology of EDs through Oxtr expression.

Conclusion: Although the current evidence does not support OXT as a standalone cause of or treatment for EDs, OXT research holds promise as a way of identifying future therapies, and OXT itself may serve as a valuable adjunct.