Intracortical recordings reveal the neuronal selectivity for bodies and body parts in the human visual cortex

Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2408871121. doi: 10.1073/pnas.2408871121. Epub 2024 Dec 9.

Abstract

Body perception plays a fundamental role in social cognition. Yet, the neural mechanisms underlying this process in humans remain elusive given the spatiotemporal constraints of functional imaging. Here, we present intracortical recordings of single- and multiunit spiking activity in two epilepsy surgery patients in or near the extrastriate body area, a critical region for body perception. Our recordings revealed a strong preference for human bodies over a large range of control stimuli. Notably, body selectivity was driven by a distinct selectivity for body parts. The observed body selectivity generalized to nonphotographic depictions of bodies including silhouettes and stick figures. Overall, our study provides unique neural data that bridge the gap between human neuroimaging and macaque electrophysiology studies, laying a solid foundation for computational models of human body processing.

Keywords: body perception; electrophysiology; human; intracortical; visual cortex.

MeSH terms

  • Adult
  • Epilepsy / physiopathology
  • Female
  • Humans
  • Male
  • Neurons* / physiology
  • Photic Stimulation / methods
  • Visual Cortex* / physiology
  • Visual Perception / physiology