β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy

Arielle L Langer; Brynn B Goggins; Erica B Esrick; Geoffrey Fell; Nancy Berliner; Katherine E Economy

doi:10.1182/blood.2024026736

β-Thalassemia minor is associated with high rates of worsening anemia in pregnancy

Blood. 2024 Dec 9:blood.2024026736. doi: 10.1182/blood.2024026736. Online ahead of print.

Authors

Arielle L Langer¹, Brynn B Goggins², Erica B Esrick³, Geoffrey Fell², Nancy Berliner¹, Katherine E Economy¹

Affiliations

¹ Brigham and Women's Hospital, Boston, Massachusetts, United States.
² Dana Farber Cancer Institute, Boston, Massachusetts, United States.
³ Boston Children's Hospital, Boston, Massachusetts, United States.

PMID: 39652827
DOI: 10.1182/blood.2024026736

Abstract

We identified 347 pregnancies in patients with beta thalassemia minor. Hemoglobin was below 9 g/dL in 31% during third trimester and 7.6% at delivery. Postpartum hemorrhage occurred in 8.9%. Forty-six percent of intravenous iron administration was to iron-replete patients.