One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi

Hong Zhang; Zhuoda Zhou; Minghua Yang; Shengyu Li; Xia Liu; Lu Jin; Qiyang Shou; Huiying Fu

doi:10.1016/j.fitote.2024.106339

One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi

Fitoterapia. 2024 Dec 8:180:106339. doi: 10.1016/j.fitote.2024.106339. Online ahead of print.

Authors

Hong Zhang¹, Zhuoda Zhou², Minghua Yang³, Shengyu Li⁴, Xia Liu⁴, Lu Jin⁴, Qiyang Shou⁵, Huiying Fu⁶

Affiliations

¹ The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: [email protected].
² Jinhua Academy of Zhejiang Chinese Medical University, Jinhua 321000, China.
³ State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
⁴ The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China.
⁵ Jinhua Academy of Zhejiang Chinese Medical University, Jinhua 321000, China. Electronic address: [email protected].
⁶ The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: [email protected].

PMID: 39657866
DOI: 10.1016/j.fitote.2024.106339

Abstract

One new polyketide asperfuranone D (1), four new sesquiterpenes derivatives aspergillone C-F (2-5) and three known compounds (6-8) were successfully isolated from Aspergillus nidulans LZ8, a fungicolous fungi from the macrofungal Ganoderma lingzhi. The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.7 cells. The results revealed that compound 5 showed moderate nitric oxide (NO) inhibitory activity with the IC₅₀ value of 13.19 ± 1.05 μM, while the IC₅₀ value of the positive control L-NMMA was 41.88 ± 0.91 μM.

Keywords: Aspergillus nidulans; Ganoderma lingzhi; NO inhibition activity; Polyketide; Sesquiterpenes.