Construction and synthesis of NiCo2O4nanozyme for enhanced antibacterial performance

Nanotechnology. 2024 Dec 27;36(9). doi: 10.1088/1361-6528/ad9d49.

Abstract

Developing effective and low-cost enzyme-like nanomaterials to kill bacteria is vital for human health. Herein, nanorod-assembled NiCo2O4microspheres were prepared though a facile hydrothermal method, andshowed highly enhanced peroxidase-like activity compared to pure Co3O4due to its large surface area and abundant active sites. The NiCo2O4possess the ability to catalyze H2O2to generate large amounts of •O2-, which can be used for bacteriostatic applications. In particular, the antibacterial system combining the spiky NiCo2O4particles and a low concentration of H2O2(100μM) exhibits an excellent bacteriostatic efficiency against bothEscherichia coli(94.44%) andStaphylococcus aureus(93.45%).

Keywords: NiCo2O4; antibacterial application; biomimetic; peroxidase-like nanozyme; porous materials.

MeSH terms

  • Anti-Bacterial Agents* / chemical synthesis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Catalysis
  • Cobalt / chemistry
  • Cobalt / pharmacology
  • Escherichia coli* / drug effects
  • Hydrogen Peroxide* / chemistry
  • Hydrogen Peroxide* / pharmacology
  • Microbial Sensitivity Tests
  • Nanotubes / chemistry
  • Oxides / chemistry
  • Oxides / pharmacology
  • Staphylococcus aureus* / drug effects

Substances

  • Anti-Bacterial Agents
  • Hydrogen Peroxide
  • Cobalt
  • Oxides