Cardiac transplantation with increased-risk donors: Trends and clinical outcomes

Background: Orthotopic Heart transplantation (OHT) is a definitive treatment for patients with advanced heart failure. Despite available evidence, recipients and some clinicians remain hesitant to accept organs from Increased Risk Donors (IRD). This study aims to report trends in acceptance of donors from IRD donors and long-term outcomes.

Methods: This study is an analysis of OHT recipients captured in the United Network of Organ Sharing (UNOS) registry from 2004 to 2021. OHT recipients were dichotomized by IRD status. Primary objectives were to report survival following OHT and trends in IRD use. Secondary objectives included all-cause hospitalizations, hospitalizations for infection, treated rejection, and graft failure.

Results: Of the 36,989 OHT recipients within the study period, 7779 (21%) were identified as recipients of IRD. Recipients of IRD were older (57 years vs 56 years, p ≤0.001), more likely to be African American (23% vs 21%, p = 0.006), blood group O (40% vs 38%, p = 0.02), have public insurance (52% vs 50%, p = 0.02), and have a BMI >30 (30% vs 29%, p = 0.003). IRD recipients had shorter waitlist time (69 days vs 76 days, p = 0.009) and similar long-term survival. IRD recipients also had lower odds of rehospitalization due to infection (OR 0.893, CI 0.842-0.947; p = 0.0002) and lower odds of rehospitalization due to rejection (OR 0.849, CI 0.782-0.921; p ≤0.001).

Conclusions: In this large multicenter study, we report that recipients of IRD had similar long-term survival and incidence of graft failure as recipients of standard risk donors. Further analysis is needed to understand observed differences in outcomes of hospitalizations for infection and treated rejection.