Significance: For therapeutic approaches for upper tract urothelial carcinomas, the absorption and reduced scattering coefficients of these tissues are essential parameters to quantitatively evaluate the distribution of light treatment effects.
Aim: The and spectra of the human ureter, fatty tissue, ureteral and renal pelvic carcinomas, and porcine ureter and fatty tissue are measured over 400 to 700 nm to evaluate projected light penetration depths .
Approach: The optical properties were determined with a double integrating sphere optical system and inverse Monte Carlo methods. was calculated and compared between normal and cancerous human tissues as well as between normal human and porcine tissues.
Results: and spectra of each tissue were determined. The of the normal human ureter was less than those of the ureteral and renal pelvic carcinomas, whereas that of the porcine ureter was similar to that of the human ureter over 400 to 600 nm and times smaller above 600 nm.
Conclusion: Optical properties of human and porcine upper urinary tracts provide insights into light distributions and the validity of ex vivo porcine models in preclinical evaluations of laser treatments.
Keywords: human tissue; laser treatment; light penetration depth; optical properties; upper tract urothelial carcinoma; upper urinary tract.
© 2024 The Authors.