Cluster of extensively drug-resistant Shigella sonnei carrying blaCTX-M-15 in Los Angeles, California, 2023 to 2024

J R Caldera; Bennett Shaw; Daniel Z Uslan; Shangxin Yang

doi:10.1016/j.ajic.2024.12.005

Cluster of extensively drug-resistant Shigella sonnei carrying bla_CTX-M-15 in Los Angeles, California, 2023 to 2024

Am J Infect Control. 2024 Dec 10:S0196-6553(24)00888-5. doi: 10.1016/j.ajic.2024.12.005. Online ahead of print.

Authors

J R Caldera¹, Bennett Shaw², Daniel Z Uslan³, Shangxin Yang⁴

Affiliations

¹ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; Infectious Disease, Quest Diagnostics, San Juan Capistrano, CA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
³ Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA.
⁴ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA. Electronic address: [email protected].

PMID: 39667596
DOI: 10.1016/j.ajic.2024.12.005

Abstract

We describe 3 cases of extensively drug-resistant Shigella sonnei infections among men who have sex with men in Los Angeles, CA. Using whole-genome sequencing, we determined that they are highly genetically related, exhibit similar antimicrobial resistomes, and appear to be distinct from other circulating strains. These cases highlight the rapid expansion of extensively drug-resistant Shigella in the United States and the urgent need for appropriate detection and management.

Keywords: CTX-M-15; Genomic Surveillance; Whole-genome Sequencing; XDR.