A metabolic pathway for improving adoptive cellular therapy

Christina M Scheffler; Paul A Beavis; Phillip K Darcy

doi:10.1016/j.ccell.2024.11.014

A metabolic pathway for improving adoptive cellular therapy

Cancer Cell. 2024 Dec 10:S1535-6108(24)00449-5. doi: 10.1016/j.ccell.2024.11.014. Online ahead of print.

Authors

Christina M Scheffler¹, Paul A Beavis², Phillip K Darcy³

Affiliations

¹ Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville VIC 3010, Australia.
² Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville VIC 3010, Australia. Electronic address: [email protected].
³ Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville VIC 3010, Australia; Department of Immunology, Monash University, Clayton, VIC, Australia. Electronic address: [email protected].

PMID: 39672167
DOI: 10.1016/j.ccell.2024.11.014

Abstract

In this issue of Cancer Cell, Qiu et al. use single-cell metabolic analysis to identify reduced mannose metabolism as a previously unknown feature of exhausted T cells. This metabolic pathway can be targeted to enhance memory and persistence of adoptively transferred T cells, resulting in improved anti-tumor efficacy.