Insights into Recent Advancements in Human and Animal Rotavirus Vaccines: Exploring New Frontiers

Ahmed H Ghonaim; Sherin R Rouby; Wedad M Nageeb; Ashraf Ahmed Elgendy; Rong Xu; Changsheng Jiang; Noha H Ghonaim; Qigai He; Wentao Li

doi:10.1016/j.virs.2024.12.001

Insights into Recent Advancements in Human and Animal Rotavirus Vaccines: Exploring New Frontiers

Virol Sin. 2024 Dec 11:S1995-820X(24)00194-9. doi: 10.1016/j.virs.2024.12.001. Online ahead of print.

Authors

Ahmed H Ghonaim¹, Sherin R Rouby², Wedad M Nageeb³, Ashraf Ahmed Elgendy⁴, Rong Xu⁵, Changsheng Jiang⁶, Noha H Ghonaim⁷, Qigai He⁸, Wentao Li⁹

Affiliations

¹ National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China; Desert Research Center, Cairo 11435, Egypt.
² Department of Veterinary Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
³ Medical Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41111, Egypt.
⁴ Department of Immunology, Faculty of Medicine, New Kaser Al-Aini Teaching Hospital, Cairo University, 11435, Egypt.
⁵ National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
⁶ Anhui Provincial Key Laboratory of Animal Nutritional Regulation and Health, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China.
⁷ Family Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, 41111, Egypt.
⁸ National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China.
⁹ National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China. Electronic address: [email protected].

PMID: 39672271
DOI: 10.1016/j.virs.2024.12.001

Abstract

Rotavirus infections cause severe gastroenteritis and dehydration in young children and animals worldwide, leading to high rates of morbidity and mortality, predominantly in low- and middle-income countries. In the past decade, substantial progress has been made in the development and implementation of rotavirus vaccines, which have been essential in alleviating the global burden of this disease, not only in human being but also in livestock species like calves and piglets, where these infections can cause significant economic losses. By synthesizing the latest research and real-world evidence, this review article is designated to provide deep insights into the current state of rotavirus vaccine technology and its global implementation as well as the application of rotavirus vaccines in veterinary settings and their importance in controlling zoonotic transmission and maintaining food security.

Keywords: Childhood diarrhea; Domestic animals; Group A rotavirus; One Health; Rotavirus vaccines.

Publication types

Review