The CALERIE Genomic Data Resource

C P Ryan; D L Corcoran; N Banskota; C Eckstein Indik; A Floratos; R Friedman; M S Kobor; V B Kraus; W E Kraus; J L MacIsaac; M C Orenduff; C F Pieper; J P White; L Ferrucci; S Horvath; K M Huffman; D W Belsky

doi:10.1038/s43587-024-00775-0

The CALERIE Genomic Data Resource

Nat Aging. 2024 Dec 13. doi: 10.1038/s43587-024-00775-0. Online ahead of print.

Authors

C P Ryan¹, D L Corcoran², N Banskota³, C Eckstein Indik⁴, A Floratos^{5

6

7}, R Friedman^{6

7}, M S Kobor^{8

9

10

11

12}, V B Kraus^{13

14

15}, W E Kraus^{13

14

15}, J L MacIsaac¹⁰, M C Orenduff^{13

14}, C F Pieper¹⁶, J P White^{13

14

15}, L Ferrucci³, S Horvath¹⁷, K M Huffman^{13

14

15}, D W Belsky^{18

19}

Affiliations

¹ Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. [email protected].
² Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
³ Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA.
⁴ Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
⁵ Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.
⁶ Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
⁷ Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA.
⁸ BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Colombia, Canada.
⁹ Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Colombia, Canada.
¹⁰ Centre for Molecular Medicine and Therapeutics, Vancouver, British Colombia, Canada.
¹¹ Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.
¹² Edwin S. H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, British Colombia, Canada.
¹³ Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
¹⁴ Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
¹⁵ Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, USA.
¹⁶ Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
¹⁷ Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
¹⁸ Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. [email protected].
¹⁹ Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. [email protected].

PMID: 39672986
DOI: 10.1038/s43587-024-00775-0

Abstract

Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 .

Associated data

ClinicalTrials.gov/NCT00427193

Abstract

Associated data

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