Systemic Antibiotic Prophylaxis Adjunctive to Surgical Reconstructive Peri-Implantitis Treatment: A Retrospective Study

Aims: To evaluate the clinical efficacy of oral systemic antibiotic prophylaxis administered along with the surgical reconstructive peri-implantitis treatment.

Methods: A total of 49 patients exhibiting 70 implants diagnosed with peri-implantitis underwent a surgical reconstructive peri-implantitis treatment. Of them, 27 patients (38 implants) received a single preoperative shot of antibiotics (2 g amoxicillin; Pre-op), 12 patients (19 implants) were prescribed with postoperative antibiotics for 3 days (500 mg amoxicillin, 3 x day, Post-op), and the remaining 10 patients (13 implants) did not receive any systemic antibiotics (No-Ab). Mean probing depth values (mean PDs; primary outcome), bleeding on probing (BOP), plaque (PI), suppuration (Sup), and deepest PDs values (max PD) were assessed prior to surgery (baseline), after 6 and 12 months. To assess the differences in changes in the clinical parameters, and disease resolution (PD ≤ 5 mm, ≤ 1 BOP site and no Sup) among the groups, logistic regression analyses were performed.

Results: After 12 months, the mean PD reduction amounted to -1.74 ± 1.56 mm, -1.91 ± 1.88 mm, and -1.13 ± 1.05 mm in the No-Ab, Pre-op, and Post-op groups, respectively, with no significant difference detected among the groups. The BOP was reduced in 60%, 59.3%, and 83.3% of the patients after 12 months in the No-Ab, Pre-op, and Post-op groups, respectively, with no significant differences among them. The PI, Sup and max PD reductions were comparable among the groups. Disease resolution after 12 months was established in 61.5%, 73.7%, and 89.5% of patients in the No-Ab, Pre-op, and Post-op groups (No-Ab vs. Pre-op: p = 0.10, No-Ab vs. Post-op: p = 0.40, Pre-op vs. Post-op: p = 0.84).

Conclusion: Systemic antibiotic prophylaxis did not improve the clinical outcomes of surgical reconstructive peri-implantitis treatment.