Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers

Cancer Commun (Lond). 2024 Dec 15. doi: 10.1002/cac2.12640. Online ahead of print.

Authors

Gavin P Dowling^{1

2}, Gordon R Daly^{1

2}, Aisling Hegarty^{1

2

3}, Michael Flanagan^{1

2}, Mihaela Ola¹, Ramón Fallon¹, Sinéad Cocchiglia¹, Vikrant Singh¹, Katherine M Sheehan⁴, Fiona Bane¹, Jason McGrath¹, Louise Watson¹, Sandra Hembrecht^{1

2}, Bryan Hennessy³, Patrick G Morris³, Arnold D K Hill^{1

2

3}, Damir Varešlija^{3

5}, Leonie S Young^{1

3}

Affiliations

¹ Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
² Department of Surgery, Beaumont Hospital, Dublin, Ireland.
³ Beaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, Ireland.
⁴ Department of Pathology, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
⁵ School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.

PMID: 39676516
DOI: 10.1002/cac2.12640

No abstract available

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