Given the critical need to preserve agricultural sustainability, there is an urgent call to address fungal infections. Our study presents a promising approach by focusing on SIX (Secreted in Xylem) proteins as a pivotal target for the development of innovative fungicidal strategies. Within the sphere of this study, we meticulously scrutinize the antifungal efficacy of our synthesized Cu(II) complex formulated as [Cu(L1)2(L2)]+(ClO4)-, where L1 represents (E)-cyclohexyl-N(pyridine-2-xlmethylene) methanamine and L2H denotes cinnamic acid, compared against a commercially available fungicide comprising 4% hexaconazole and 68% zineb. Employing in silico methodologies, we undertake a comparative analysis targeting SIX proteins to discern the potency of our compound. The X-ray diffraction, 1H NMR, and FTIR spectroscopic techniques were utilized to elucidate the structure of the complex methodically. The lipophilicity test of the complex signifies its potential lipophilic nature and prompted further investigation into the complex's interaction with DNA (DNA) and bovine serum albumin (BSA). The binding constant values suggested a notable interaction between the complex and both DNA and BSA. The antifungal test reveal that our complex emerges as a potent contender in the battle against Fusarium equisetum (F.E.), exhibiting a commendable efficacy that positions it as a viable substitute for the incumbent commercial fungicide. This discovery predicts well the prospect of bolstering agricultural resilience and safeguarding global food security in the face of pervasive fungal threats.
© 2024 The Authors. Published by American Chemical Society.