Two new sesquiterpene eudesmanolides from the Croton cascarilloides Raeusch

Two new sesquiterpene eudesmanolides, 5α-hydroxy-eudesman-7(11)-en-8α(12)-olide (1), and 5α-hydroxy-7(11)-en-8-oxo-eudesmane (2), along with six known sesquiterpene eudesmanolides, were isolated from the leaves and twigs of Croton cascarilloides Raeusch. The structures of these compounds were established basis on NMR and MS spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated. Compounds 6 (IC₅₀ 115.38 ± 8.81 μg/mL) and 8 (IC₅₀ 72.04 ± 1.92 μg/mL) showed inhibitory activity against HL-60 leukaemia cells, while compounds 2 exhibited inhibitory activity against both HL-60 leukaemia cells (IC₅₀ 178.34 ± 6.43 μg/mL) and SMMC-7721 hepatoma cells (IC₅₀ 188.87 ± 7.40 μg/mL).