Nanoparticle biosensors for cardiovascular disease detection

Mohamed J Saadh; Faris Anad Muhammad; Rafid Jihad Albadr; Ashok Kumar Bishoyi; Suhas Ballal; Lakshay Bareja; K Satyam Naidu; Jasur Rizaev; Waam Mohammed Taher; Mariem Alwan; Mahmood Jasem Jawad; Ali M Ali Al-Nuaimi

doi:10.1016/j.cca.2024.120094

Nanoparticle biosensors for cardiovascular disease detection

Clin Chim Acta. 2024 Dec 15:567:120094. doi: 10.1016/j.cca.2024.120094. Online ahead of print.

Authors

Affiliations

¹ Faculty of Pharmacy, Middle East University, Amman 11831, Jordan. Electronic address: [email protected].
² College of Pharmacy, Alnoor University, Nineveh, Iraq. Electronic address: [email protected].
³ Ahl al Bayt University, Kerbala, Iraq. Electronic address: [email protected].
⁴ Marwadi University Research Center, Department of Microbiology, Faculty of Science Marwadi University, Rajkot 360003, Gujarat, India. Electronic address: [email protected].
⁵ Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India. Electronic address: [email protected].
⁶ Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura 140401, Punjab, India. Electronic address: [email protected].
⁷ Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh-531162, India. Electronic address: [email protected].
⁸ Department of Public health and Healthcare management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan. Electronic address: [email protected].
⁹ College of Nursing, National University of Science and Technology, Dhi Qar, Iraq. Electronic address: [email protected].
¹⁰ Pharmacy college, Al-Farahidi University, Baghdad, Iraq. Electronic address: [email protected].
¹¹ Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq. Electronic address: [email protected].
¹² Gilgamesh Ahliya University, Baghdad, Iraq. Electronic address: [email protected].

PMID: 39681229
DOI: 10.1016/j.cca.2024.120094

Abstract

Early detection and management of cardiovascular diseases (CVDs) are crucial for patient survival and long-term health. CVD biomarkers such as cardiac Troponin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase MB (CK-MB), Galectin-3 (Gal-3), etc are released into the circulation following heart muscle injury, ie, acute myocardial infarction (AMI). Biosensor technology including the use of nanoparticles can be designed to target specific biomarkers associated with CVD, enabling early detection and more rapid intervention to decrease morbidity and mortality. To date, with the combination of developed nanoparticles, several optical and electrochemical-based biosensors have successfully been used detection of CVD biomarkers. Nanomaterials, when introduced as the modifiers of sensor surfaces like electrodes and gold chips, can result in the more comprehensive and more effective immobilization of capture molecules, ie, antibodies, aptamers and other ligands, due to their large surface area. In recent years, inorganic nanoparticles have regularly been used in the production of biosensors mostly due to their excellent response intensification, adaptable functionalization chemistry, shape control, good biocompatibility, and great stability. In this review, we discuss the application of different kinds of nanoparticles for the sensitive and specific detection of CVD biomarkers.

Keywords: Biomarkers; Biosensors; CVD; Detection; Nanoparticles.

Publication types

Review