Regio- and Stereoselective Electro-Mediated Carboalkoxylation of 1,3-Dienes

Org Lett. 2024 Dec 27;26(51):11105-11110. doi: 10.1021/acs.orglett.4c03922. Epub 2024 Dec 16.

Abstract

1,3-Dienes are versatile raw materials for building molecular complexity. We report herein mild conditions for the regio- and stereoselective [only the (E) isomer obtained] 1,4-carboalkoxylation of 1,3-dienes. This electrochemical multicomponent reaction provides an eco-efficient and straightforward access to a diverse range of (E)-polyfunctionalized allyl ether products, without requiring any metal catalyst.