Objectives: To observe the clinical effect on perimenopausal dry eye disease treated with He's fire needle therapy combined with walnut-shell moxibustion.
Methods: A total of 60 patients with perimenopausal dry eye disease were randomized into an observation group (30 cases) and a control group (30 cases). In the observation group, the pricking technique with fire needle was operated at bilateral Naokong (GB19), Feishu (BL13), Xinshu (BL15), Ganshu (BL18), Pishu (BL20), Shenshu (BL23), 3 times a week, for 4 weeks, and the walnut-shell moxibustion was combined, 30 minutes each time, 3 times a week, for 4 weeks. In the control group, hyaluronic acid sodium eye drops were used, one drop each time, 3 times a day, for 4 weeks. Before and after treatment, the scores of the questionnaire for dry eye disease in China, the result of lacrimal secretion test (Schimer Ⅰ test, SⅠT) and tear film break-up time(BUT), as well as the modified Kupperman score were evaluated in the two groups. The clinical effect was compared between the two groups.
Results: After 4 weeks of treatment, the results of SⅠT and BUT increased (P<0.001), while the scores of the questionnaire for dry eye disease in China, the modified Kupperman score decreased (P<0.001) in the two groups when compared with the baseline. In the observation group, the result of SⅠT and BUT were higher than those of the control group (P<0.05), while the scores of the questionnaire for dry eye disease in China, and the modified Kupperman score was lower (P<0.05). The marked effective rate (30/60, 50.0%) in the observation group was better than that (10/60, 16.7%) of the control group (P<0.05).
Conclusions: In treatment of perimenopausal dry eye disease, the combined therapy of fire needling and walnut-shell moxibustion obtains the superior effect to hyaluronic acid sodium eye drops. This combined therapy can effectively relieve the eye symptoms, increase the secretion of tears, prolong BUT, and ameliorate systemic symptoms.
目的: 观察贺氏火针联合核桃壳灸治疗围绝经期干眼的临床疗效。方法: 选取60例围绝经期干眼患者，随机分为观察组（30例）和对照组（30例）。观察组予火针点刺双侧脑空、五脏俞（肺俞、心俞、肝俞、脾俞、肾俞）联合核桃壳灸，每次施灸30 min，每周3次，共治疗4周；对照组予玻璃酸钠滴眼液，1滴/次，3次/d，共治疗4周。评估两组患者治疗前后的中国干眼问卷量表评分、泪液分泌试验（SⅠT）、泪膜破裂时间（BUT）、改良Kupperman评分，并比较两组的临床疗效。结果: 治疗4周后，两组的SⅠT、BUT均较治疗前升高（P<0.001），中国干眼问卷量表评分、改良Kupperman评分均较治疗前降低（P<0.001）；观察组SⅠT、BUT均较对照组升高（P<0.05），中国干眼问卷量表评分、改良Kupperman评分均较对照组降低（P<0.05）。观察组显效率（30/60，50.0%）优于对照组（10/60，16.7%，P<0.05）。结论: 火针联合核桃壳灸治疗围绝经期干眼的疗效优于玻璃酸钠滴眼液治疗，能够较好地缓解患者眼部症状，增加泪液分泌量，延长BUT，并改善全身症状。.
Keywords: Back- shu points of five zang organs; Dry eye disease; Fire needle therapy; Naokong (GB19); Perimenopause; Walnut-shell moxibustion.