From bits to bedside: entering the age of digital twins in cardiac electrophysiology

Europace. 2024 Dec 3;26(12):euae295. doi: 10.1093/europace/euae295.

Abstract

This State of the Future Review describes and discusses the potential transformative power of digital twins in cardiac electrophysiology. In this 'big picture' approach, we explore the evolution of mechanistic modelling based digital twins, their current and immediate clinical applications, and envision a future where continuous updates, advanced calibration, and seamless data integration redefine clinical practice of cardiac electrophysiology. Our aim is to inspire researchers and clinicians to embrace the extraordinary possibilities that digital twins offer in the pursuit of precision medicine.

Keywords: Atrial fibrillation; CRT; Computational modelling; Digital twin; Electrophysiology; Personalized treatment; Ventricular tachycardia.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac / diagnosis
  • Arrhythmias, Cardiac / physiopathology
  • Arrhythmias, Cardiac / therapy
  • Cardiac Electrophysiology
  • Electrophysiologic Techniques, Cardiac*
  • Humans
  • Models, Cardiovascular
  • Precision Medicine / methods