Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

Rania Mhenni; Sarah Dellière; Chiheb Ben Maaouia; Samia Hamane; Benjamin Deniau; Thibault Mahévas; Maité Chaussard; Maxime Coutrot; Lucie Guillemet; Alexandru Cupaciu; Alexandre Pharaboz; Thais Walter; Louis Boutin; Mourad Benyamina; Hélène Corte; Charles Delale; Marc Chaouat; Amélie Guihot; Fanny Lanternier; Alexandre Alanio; François Dépret; Alexandra Serris; Emmanuel Dudoignon

doi:10.1016/j.diagmicrobio.2024.116653

Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

Diagn Microbiol Infect Dis. 2024 Dec 14;111(3):116653. doi: 10.1016/j.diagmicrobio.2024.116653. Online ahead of print.

Authors

Rania Mhenni¹, Sarah Dellière², Chiheb Ben Maaouia¹, Samia Hamane³, Benjamin Deniau⁴, Thibault Mahévas⁵, Maité Chaussard¹, Maxime Coutrot¹, Lucie Guillemet¹, Alexandru Cupaciu¹, Alexandre Pharaboz¹, Thais Walter⁶, Louis Boutin⁷, Mourad Benyamina¹, Hélène Corte⁸, Charles Delale⁹, Marc Chaouat¹⁰, Amélie Guihot¹¹, Fanny Lanternier¹², Alexandre Alanio², François Dépret⁴, Alexandra Serris¹², Emmanuel Dudoignon¹³

Affiliations

¹ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France.
² University of Paris Cité, Paris, France; Department of mycology and parasitology, Paris.
³ Department of mycology and parasitology, Paris.
⁴ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, France Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France; INI-CRCT Network, Nancy, France; FHU PROMICE, Paris, France.
⁵ Department dermatology, Saint Louis Hospital.
⁶ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris Cité, Paris, France.
⁷ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, France Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France.
⁸ Assistance Publique-Hôpitaux de Paris (AP-HP), Saint Louis Hospital, abdominal surgery.
⁹ Intensive Care Unit - CH Blois, France.
¹⁰ University of Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Saint Louis Hospital, plastic surgery.
¹¹ Department of immunology, Pitié-salpétrière, Paris, France.
¹² University of Paris Cité, Paris, France; Department of infectious disease, Necker Hospital.
¹³ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, France Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France; INI-CRCT Network, Nancy, France; FHU PROMICE, Paris, France. Electronic address: [email protected].

PMID: 39689401
DOI: 10.1016/j.diagmicrobio.2024.116653

Abstract

Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.

Keywords: Immunostimulation; Immunotherapy; Mucormycosis; Rhizopus microsporus.

Publication types

Case Reports